Shiga Toxin Promotes Podocyte Injury in Experimental Hemolytic Uremic Syndrome via Activation of the Alternative Pathway of Complement

Shiga toxin (Stx)–producing Escherichia coli is the offending agent of postdiarrhea-associated hemolytic uremic syndrome (HUS), a disorder of glomerular ischemic damage and widespread microvascular thrombosis. We previously documented that Stx induces glomerular complement activation, generating C3a...

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Detalhes bibliográficos
Main Authors: Locatelli, Monica, Buelli, Simona, Pezzotta, Anna, Corna, Daniela, Perico, Luca, Tomasoni, Susanna, Rottoli, Daniela, Rizzo, Paola, Conti, Debora, Thurman, Joshua M., Remuzzi, Giuseppe, Zoja, Carlamaria, Morigi, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2014
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116050/
https://ncbi.nlm.nih.gov/pubmed/24578132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013050450
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