Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN)

Epigenetic regulation plays an important role in the development and progression of nasopharyngeal carcinoma (NPC), but the epigenetic mechanisms underlying NPC metastasis remain poorly understood. Here, we demonstrate that hypermethylation of the UCHL1 promoter leads to its downregulation in NPC. R...

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發表在:Cells
Main Authors: Zhao, Yin, Lei, Yuan, He, Shi-Wei, Li, Ying-Qin, Wang, Ya-Qin, Hong, Xiao-Hong, Liang, Ye-Lin, Li, Jun-Yan, Chen, Yang, Luo, Wei-Jie, Zhang, Pan-Pan, Yang, Xiao-Jing, He, Qing-Mei, Ma, Jun, Liu, Na, Tang, Ling-Long
格式: Artigo
語言:Inglês
出版: MDPI 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140450/
https://ncbi.nlm.nih.gov/pubmed/32120844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9030559
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