Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN)

Epigenetic regulation plays an important role in the development and progression of nasopharyngeal carcinoma (NPC), but the epigenetic mechanisms underlying NPC metastasis remain poorly understood. Here, we demonstrate that hypermethylation of the UCHL1 promoter leads to its downregulation in NPC. R...

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Publié dans:Cells
Auteurs principaux: Zhao, Yin, Lei, Yuan, He, Shi-Wei, Li, Ying-Qin, Wang, Ya-Qin, Hong, Xiao-Hong, Liang, Ye-Lin, Li, Jun-Yan, Chen, Yang, Luo, Wei-Jie, Zhang, Pan-Pan, Yang, Xiao-Jing, He, Qing-Mei, Ma, Jun, Liu, Na, Tang, Ling-Long
Format: Artigo
Langue:Inglês
Publié: MDPI 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140450/
https://ncbi.nlm.nih.gov/pubmed/32120844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9030559
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