Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN)

Epigenetic regulation plays an important role in the development and progression of nasopharyngeal carcinoma (NPC), but the epigenetic mechanisms underlying NPC metastasis remain poorly understood. Here, we demonstrate that hypermethylation of the UCHL1 promoter leads to its downregulation in NPC. R...

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Pubblicato in:Cells
Autori principali: Zhao, Yin, Lei, Yuan, He, Shi-Wei, Li, Ying-Qin, Wang, Ya-Qin, Hong, Xiao-Hong, Liang, Ye-Lin, Li, Jun-Yan, Chen, Yang, Luo, Wei-Jie, Zhang, Pan-Pan, Yang, Xiao-Jing, He, Qing-Mei, Ma, Jun, Liu, Na, Tang, Ling-Long
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140450/
https://ncbi.nlm.nih.gov/pubmed/32120844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9030559
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