Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN)

Epigenetic regulation plays an important role in the development and progression of nasopharyngeal carcinoma (NPC), but the epigenetic mechanisms underlying NPC metastasis remain poorly understood. Here, we demonstrate that hypermethylation of the UCHL1 promoter leads to its downregulation in NPC. R...

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Main Authors: Zhao, Yin, Lei, Yuan, He, Shi-Wei, Li, Ying-Qin, Wang, Ya-Qin, Hong, Xiao-Hong, Liang, Ye-Lin, Li, Jun-Yan, Chen, Yang, Luo, Wei-Jie, Zhang, Pan-Pan, Yang, Xiao-Jing, He, Qing-Mei, Ma, Jun, Liu, Na, Tang, Ling-Long
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2020
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140450/
https://ncbi.nlm.nih.gov/pubmed/32120844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9030559
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