LRRC15 Targeting in Soft-Tissue Sarcomas: Biological and Clinical Implications

Background: LRRC15 is a member of the LRR (leucine-rich repeat) superfamily present on tumor-associated fibroblasts (CAFs) and stromal cells. The expression of LRRC15 is upregulated by the pro-inflammatory cytokine TGFβ. ABBV-085 is a monomethyl auristatin E (MMAE)-containing antibody-drug conjugate...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Ben-Ami, Eytan, Perret, Raul, Huang, Ying, Courgeon, Félicie, Gokhale, Prafulla C., Laroche-Clary, Audrey, Eschle, Benjamin K., Velasco, Valérie, Le Loarer, François, Algeo, Marie-Paule, Purcell, James, Demetri, George D., Italiano, Antoine
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140027/
https://ncbi.nlm.nih.gov/pubmed/32210091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12030757
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