USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy

PRKN/parkin activation through phosphorylation of its ubiquitin and ubiquitin-like domain by PINK1 is critical in mitophagy induction for eliminating the damaged mitochondria. Deubiquitinating enzymes (DUBs) functionally reversing PRKN ubiquitination are critical in controlling the magnitude of PRKN...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Niu, Kaifeng, Fang, Hongbo, Chen, Zixiang, Zhu, Yuqi, Tan, Qunsong, Wei, Di, Li, Yueyang, Balajee, Adayabalam S., Zhao, Yongliang
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138199/
https://ncbi.nlm.nih.gov/pubmed/31432739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1656957
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