RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks

Ubiquitination-dependent DNA damage response (DDR) signals play a critical role in the cellular choice of DNA damage repair pathways. Human DNA helicase RecQL4 participates in DNA replication and repair, and loss of RecQL4 is associated with autosomal recessive genetic disorders characterized by gen...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: Tan, Qunsong, Niu, Kaifeng, Zhu, Yuqi, Chen, Zixiang, Li, Yueyang, Li, Mengge, Wei, Di, Balajee, Adayabalam S., Fang, Hongbo, Zhao, Yongliang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935965/
https://ncbi.nlm.nih.gov/pubmed/33674555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-021-00315-0
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