Determining isoleucine side-chain rotamer-sampling in proteins from (13)C chemical shift

Chemical shifts are often the only nuclear magnetic resonance parameter that can be obtained for challenging macromolecular systems. Here we present a framework to derive the conformational sampling of isoleucine side chains from (13)C chemical shifts and demonstrate that side-chain conformations in...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Chem Commun (Camb)
Prif Awduron: Siemons, Lucas, Uluca-Yazgi, Boran, Pritchard, Ruth B., McCarthy, Stephen, Heise, Henrike, Hansen, D. Flemming
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Royal Society of Chemistry 2019
Pynciau:
Chemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138115/
https://ncbi.nlm.nih.gov/pubmed/31642826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cc06496f
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