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Aromatic side-chain flips orchestrate the conformational sampling of functional loops in human histone deacetylase 8

Human histone deacetylase 8 (HDAC8) is a key hydrolase in gene regulation and an important drug-target. High-resolution structures of HDAC8 in complex with substrates or inhibitors are available, which have provided insights into the bound state of HDAC8 and its function. Here, using long all-atom u...

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Vydáno v:Chem Sci
Hlavní autoři: Shukla, Vaibhav Kumar, Siemons, Lucas, Gervasio, Francesco L., Hansen, D. Flemming
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society of Chemistry 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8278956/
https://ncbi.nlm.nih.gov/pubmed/34349901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc01929e
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