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Aromatic side-chain flips orchestrate the conformational sampling of functional loops in human histone deacetylase 8
Human histone deacetylase 8 (HDAC8) is a key hydrolase in gene regulation and an important drug-target. High-resolution structures of HDAC8 in complex with substrates or inhibitors are available, which have provided insights into the bound state of HDAC8 and its function. Here, using long all-atom u...
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| Pubblicato in: | Chem Sci |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Royal Society of Chemistry
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8278956/ https://ncbi.nlm.nih.gov/pubmed/34349901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc01929e |
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