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Analysis of Side-Chain Rotamers in Transmembrane Proteins

We measured the frequency of side-chain rotamers in 14 α-helical and 16 β-barrel membrane protein structures and found that the membrane environment considerably perturbs the rotamer frequencies compared to soluble proteins. Although there are limited experimental data, we found statistically signif...

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Bibliographic Details
Main Authors: Chamberlain, Aaron K., Bowie, James U.
Format: Artigo
Language:Inglês
Published: Biophysical Society 2004
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304812/
https://ncbi.nlm.nih.gov/pubmed/15339811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.044024
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