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Recruitment of Ubiquitin within an E2 Chain Elongation Complex

The ubiquitin (Ub) proteolysis pathway uses an E1, E2, and E3 enzyme cascade to label substrate proteins with ubiquitin and target them for degradation. The mechanisms of ubiquitin chain formation remain unclear and include a sequential addition model, in which polyubiquitin chains are built unit by...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Cook, Benjamin W., Lacoursiere, Rachel E., Shaw, Gary S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136282/
https://ncbi.nlm.nih.gov/pubmed/32101714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.02.012
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