Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation

Several mechanisms have been proposed for the synthesis of substrate-linked ubiquitin chains. HECT ligases directly catalyse protein ubiquitination and have been found to non-covalently interact with ubiquitin. We report crystal structures of the Nedd4 HECT domain, alone and in complex with ubiquiti...

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Autors principals: Maspero, Elena, Mari, Sara, Valentini, Eleonora, Musacchio, Andrea, Fish, Alexander, Pasqualato, Sebastiano, Polo, Simona
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
Matèries:
Scientific Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077247/
https://ncbi.nlm.nih.gov/pubmed/21399620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.21
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