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Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase promoting complex
The anaphase promoting complex (APC) is the crucial ubiquitin ligase targeting the regulatory machinery of the cell cycle. Emi1, a major modulator of APC activity, is thought to act competitively as a pseudosubstrate. We show that the modulation of APC activity is more subtle: Emi1 inhibits ubiquity...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3812805/ https://ncbi.nlm.nih.gov/pubmed/23708001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2755 |
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