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Mechanism of Ubiquitin-Chain Formation by the human Anaphase-Promoting Complex

The Anaphase-Promoting Complex (APC/C) orchestrates progression through mitosis by decorating cell cycle regulators with ubiquitin chains. To nucleate chain formation, the APC/C links ubiquitin to a lysine in substrates, but it elongates chains by modifying lysine residues in attached ubiquitin moie...

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Autors principals: Jin, Lingyan, Williamson, Adam, Banerjee, Sudeep, Philipp, Isabelle, Rape, Michael
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696189/
https://ncbi.nlm.nih.gov/pubmed/18485873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.04.012
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