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Mechanism of Ubiquitin-Chain Formation by the human Anaphase-Promoting Complex
The Anaphase-Promoting Complex (APC/C) orchestrates progression through mitosis by decorating cell cycle regulators with ubiquitin chains. To nucleate chain formation, the APC/C links ubiquitin to a lysine in substrates, but it elongates chains by modifying lysine residues in attached ubiquitin moie...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2696189/ https://ncbi.nlm.nih.gov/pubmed/18485873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.04.012 |
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