Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma

Brain metastases from lung adenocarcinoma (BM-LUAD) cause significant patient mortality. To identify genomic alterations that promote brain metastases, we performed whole-exome sequencing of 73 BM-LUAD cases. Using case-control analyses, we discovered candidate drivers of brain metastasis by identif...

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Publicado no:Nat Genet
Main Authors: Shih, David J. H., Nayyar, Naema, Bihun, Ivanna, Dagogo-Jack, Ibiayi, Gill, Corey M., Aquilanti, Elisa, Bertalan, Mia, Kaplan, Alexander, D’Andrea, Megan R., Chukwueke, Ugonma, Ippen, Franziska Maria, Alvarez-Breckenridge, Christopher, Camarda, Nicholas D., Lastrapes, Matthew, McCabe, Devin, Kuter, Ben, Kaufman, Benjamin, Strickland, Matthew R., Martinez-Gutierrez, Juan Carlos, Nagabhushan, Deepika, De Sauvage, Magali, White, Michael D., Castro, Brandyn A., Hoang, Kaitlin, Kaneb, Andrew, Batchelor, Emily D., Paek, Sun Ha, Park, Sun Hye, Martinez-Lage, Maria, Berghoff, Anna S., Merrill, Parker, Gerstner, Elizabeth R., Batchelor, Tracy T., Frosch, Matthew P., Frazier, Ryan P., Borger, Darrell R., Iafrate, A. John, Johnson, Bruce E., Santagata, Sandro, Preusser, Matthias, Cahill, Daniel P., Carter, Scott L., Brastianos, Priscilla K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136154/
https://ncbi.nlm.nih.gov/pubmed/32203465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0592-7
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