MYD88 L265P mutation and CDKN2A loss are early mutational events in primary central nervous system diffuse large B-cell lymphomas

The genetic alterations that define primary central nervous system lymphoma (PCNSL) are incompletely elucidated, and the genomic evolution from diagnosis to relapse is poorly understood. We performed whole-exome sequencing (WES) on 36 PCNSL patients and targeted MYD88 sequencing on a validation coho...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Blood Adv
Κύριοι συγγραφείς: Nayyar, Naema, White, Michael D., Gill, Corey M., Lastrapes, Matthew, Bertalan, Mia, Kaplan, Alexander, D’Andrea, Megan R., Bihun, Ivanna, Kaneb, Andrew, Dietrich, Jorg, Ferry, Judith A., Martinez-Lage, Maria, Giobbie-Hurder, Anita, Borger, Darrell R., Rodriguez, Fausto J., Frosch, Matthew P., Batchelor, Emily, Hoang, Kaitlin, Kuter, Benjamin, Fortin, Sarah, Holdhoff, Matthias, Cahill, Daniel P., Carter, Scott, Brastianos, Priscilla K., Batchelor, Tracy T.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society of Hematology 2019
Θέματα:
Lymphoid Neoplasia
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6373750/
https://ncbi.nlm.nih.gov/pubmed/30723112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018027672
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