CSIG-29. THE DUAL PI3K/mTOR-PATHWAY INHIBITOR GDC-0084 ACHIEVES ANTITUMOR ACTIVITY IN BREAST CANCER BRAIN METASTASES IN VITRO AND IN VIVO

Breast cancer is the second most common primary tumor leading to brain metastases in adult cancer patients. Previous studies have shown that the PI3K/AKT/mTOR pathway in breast cancer brain metastasis is activated in up to 70% of analyzed tumors. However, there are no approved agents targeting this...

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Publicado en:Neuro Oncol
Autores principales: Ippen, Franziska, Alvarez-Breckenridge, Christopher, Kuter, Benjamin, Fink, Alexandria, Bihun, Ivanna, Penson, Tristan, Ning, Jianfang, Wakimoto, Hiroaki, Brastianos, Priscilla
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216688/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.195
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