Resolving the phylogenetic origin of glioblastoma via multifocal genomic analysis of pre-treatment and treatment-resistant autopsy specimens

Glioblastomas are malignant neoplasms composed of diverse cell populations. This intratumoral diversity has an underlying architecture, with a hierarchical relationship through clonal evolution from a common ancestor. Therapies are limited by emergence of resistant subclones from this phylogenetic r...

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Detalhes bibliográficos
Publicado no:NPJ Precis Oncol
Main Authors: Brastianos, Priscilla K., Nayyar, Naema, Rosebrock, Daniel, Leshchiner, Ignaty, Gill, Corey M., Livitz, Dimitri, Bertalan, Mia S., D’Andrea, Megan, Hoang, Kaitlin, Aquilanti, Elisa, Chukwueke, Ugonma N., Kaneb, Andrew, Chi, Andrew, Plotkin, Scott, Gerstner, Elizabeth R., Frosch, Mathew P., Suva, Mario L., Cahill, Daniel P., Getz, Gad, Batchelor, Tracy T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871833/
https://ncbi.nlm.nih.gov/pubmed/29872714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41698-017-0035-9
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