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Aneuploidy and gene expression: is there dosage compensation?

Aneuploidy (i.e., abnormal chromosome number) is the leading cause of miscarriage and congenital defects in humans. Moreover, aneuploidy is ubiquitous in cancer. The deleterious phenotypes associated with aneuploidy are likely a result of the imbalance in the levels of gene products derived from the...

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Detalhes bibliográficos
Publicado no:Epigenomics
Main Authors: Kojima, Shihoko, Cimini, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: Future Medicine Ltd 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132608/
https://ncbi.nlm.nih.gov/pubmed/31755744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/epi-2019-0135
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