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Dosage compensation plans: protein aggregation provides additional insurance against aneuploidy
Gene dosage alterations caused by aneuploidy are a common feature of most cancers yet pose severe proteotoxic challenges. Therefore, cells have evolved various dosage compensation mechanisms to limit the damage caused by the ensuing protein level imbalances. For instance, for heteromeric protein com...
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| Publicado no: | Genes Dev |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6672054/ https://ncbi.nlm.nih.gov/pubmed/31371460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.329383.119 |
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