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Aneuploidy and gene expression: is there dosage compensation?

Aneuploidy (i.e., abnormal chromosome number) is the leading cause of miscarriage and congenital defects in humans. Moreover, aneuploidy is ubiquitous in cancer. The deleterious phenotypes associated with aneuploidy are likely a result of the imbalance in the levels of gene products derived from the...

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Bibliografiske detaljer
Udgivet i:Epigenomics
Main Authors: Kojima, Shihoko, Cimini, Daniela
Format: Artigo
Sprog:Inglês
Udgivet: Future Medicine Ltd 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132608/
https://ncbi.nlm.nih.gov/pubmed/31755744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/epi-2019-0135
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