Murine Coronavirus Spike Glycoprotein Mediates Degree of Viral Spread, Inflammation, and Virus-Induced Immunopathology in the Central Nervous System

The mouse hepatitis virus (MHV) spike glycoprotein is a major determinant of neurovirulence. We investigated how alterations in spike affect neurovirulence using two isogenic recombinant viruses differing exclusively in spike. S(4)R, containing the MHV-4 spike gene, is dramatically more neurovirulen...

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Опубликовано в: :Virology
Главные авторы: Phillips, Joanna J., Chua, Ming Ming, Rall, Glenn F., Weiss, Susan R.
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier Science (USA). 2002
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7131834/
https://ncbi.nlm.nih.gov/pubmed/12359451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1006/viro.2002.1551
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