Amino acid substitutions within the heptad repeat domain 1 of murine coronavirus spike protein restrict viral antigen spread in the central nervous system

Targeted recombination was carried out to select mouse hepatitis viruses (MHVs) in a defined genetic background, containing an MHV-JHM spike gene encoding either three heptad repeat 1 (HR1) substitutions (Q1067H, Q1094H, and L1114R) or L1114R alone. The recombinant virus, which expresses spike with...

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Publicado en:Virology
Main Authors: Tsai, Jean C, Groot, Linda de, Pinon, Josefina D, Iacono, Kathryn T, Phillips, Joanna J, Seo, Su-hun, Lavi, Ehud, Weiss, Susan R
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Science (USA). 2003
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125853/
https://ncbi.nlm.nih.gov/pubmed/12919742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0042-6822(03)00248-4
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