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The Spike Glycoprotein of Murine Coronavirus MHV-JHM Mediates Receptor-Independent Infection and Spread in the Central Nervous Systems of Ceacam1a(−/−) Mice

The MHV-JHM strain of the murine coronavirus mouse hepatitis virus is much more neurovirulent than the MHV-A59 strain, although both strains use murine CEACAM1a (mCEACAM1a) as the receptor to infect murine cells. We previously showed that Ceacam1a(−/−) mice are completely resistant to MHV-A59 infect...

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Detalhes bibliográficos
Main Authors: Miura, Tanya A., Travanty, Emily A., Oko, Lauren, Bielefeldt-Ohmann, Helle, Weiss, Susan R., Beauchemin, Nicole, Holmes, Kathryn V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224565/
https://ncbi.nlm.nih.gov/pubmed/18003729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01851-07
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