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The N-Terminal Domain of the Murine Coronavirus Spike Glycoprotein Determines the CEACAM1 Receptor Specificity of the Virus Strain

Using isogenic recombinant murine coronaviruses expressing wild-type murine hepatitis virus strain 4 (MHV-4) or MHV-A59 spike glycoproteins or chimeric MHV-4/MHV-A59 spike glycoproteins, we have demonstrated the biological functionality of the N-terminus of the spike, encompassing the receptor bindi...

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Détails bibliographiques
Auteurs principaux: Tsai, Jean C., Zelus, Bruce D., Holmes, Kathryn V., Weiss, Susan R.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2003
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC140794/
https://ncbi.nlm.nih.gov/pubmed/12502800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.2.841-850.2003
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