Pathogenesis of Chimeric MHV4/MHV-A59 Recombinant Viruses: the Murine Coronavirus Spike Protein Is a Major Determinant of Neurovirulence

The mouse hepatitis virus (MHV) spike glycoprotein, S, has been implicated as a major determinant of viral pathogenesis. In the absence of a full-length molecular clone, however, it has been difficult to address the role of individual viral genes in pathogenesis. By using targeted RNA recombination...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Phillips, Joanna J., Chua, Ming Ming, Lavi, Ehud, Weiss, Susan R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104302/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10438865/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.9.7752-7760.1999
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