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Cobalt-Catalyzed Hydrogen Atom Transfer Induces Bicyclizations that Tolerate Electron-rich and –deficient Intermediate Alkenes

A novel Co(II)-catalyzed polyene cyclization was developed that is uniquely effective when performed in hexafluoroisopropanol as solvent. The process is presumably initiated by metal-catalyzed hydrogen atom transfer (MHAT) to 1,1-disubstituted or monosubstituted alkenes, and the reaction is remarkab...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Vrubliauskas, Darius, Vanderwal, Christopher D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7124983/
https://ncbi.nlm.nih.gov/pubmed/31991035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202000252
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