Gasdermin E suppresses tumor growth by activating anti-tumor immunity

Cleavage of the gasdermins to produce a pore-forming N-terminal fragment causes inflammatory death (pyroptosis)(1). Caspase-3 cleaves gasdermin E (GSDME, also known as DFNA5), mutated in familial aging-related hearing loss(2), which converts noninflammatory apoptosis to pyroptosis in GSDME-expressin...

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Publicat a:Nature
Autors principals: Zhang, Zhibin, Zhang, Ying, Xia, Shiyu, Kong, Qing, Li, Shunying, Liu, Xing, Junqueira, Caroline, Meza-Sosa, Karla F., Temy Mok, Mo Yin, Ansara, James, Sengupta, Satyaki, Yao, Yandan, Wu, Hao, Lieberman, Judy
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7123794/
https://ncbi.nlm.nih.gov/pubmed/32188940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2071-9
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