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Inflammasome - activated gasdermin D causes pyroptosis by forming membrane pores

Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to microbial infection and danger signals. When activated, they cleave mouse and human gasdermin D (GSDMD) after Asp276 and Asp275, respectively, to generate an N-terminal cleavage product (GSDMD-NT) that triggers inflammatory...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nature
Prif Awduron: Liu, Xing, Zhang, Zhibin, Ruan, Jianbin, Pan, Youdong, Magupalli, Venkat Giri, Wu, Hao, Lieberman, Judy
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539988/
https://ncbi.nlm.nih.gov/pubmed/27383986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature18629
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