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Inflammasome - activated gasdermin D causes pyroptosis by forming membrane pores
Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to microbial infection and danger signals. When activated, they cleave mouse and human gasdermin D (GSDMD) after Asp276 and Asp275, respectively, to generate an N-terminal cleavage product (GSDMD-NT) that triggers inflammatory...
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| 出版年: | Nature |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5539988/ https://ncbi.nlm.nih.gov/pubmed/27383986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature18629 |
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