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Cryo-EM structure of the gasdermin A3 membrane pore
Gasdermins mediate inflammatory cell death after cleavage by caspases or other, unknown enzymes. The cleaved N-terminal fragments bind to acidic membrane lipids to form pores, but the mechanism of pore formation remains unresolved. Here we present the cryo-electron microscopy structures of the 27-fo...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6007975/ https://ncbi.nlm.nih.gov/pubmed/29695864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0058-6 |
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