FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells assembles large complexes called inflammasomes, which activate inflammatory caspases to process cytokines (IL-1β) and gasdermin D (GSDMD). Cleaved GSDMD forms membrane pores, leading to cytokine release and inflammator...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Hu, Jun Jacob, Liu, Xing, Xia, Shiyu, Zhang, Zhibin, Zhang, Ying, Zhao, Jingxia, Ruan, Jianbin, Luo, Xuemei, Lou, Xiwen, Bai, Yang, Wang, Junhong, Hollingsworth, L. Robert, Magupalli, Venkat Giri, Zhao, Li, Luo, Hongbo R., Kim, Justin, Lieberman, Judy, Wu, Hao
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316630/
https://ncbi.nlm.nih.gov/pubmed/32367036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-0669-6
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