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Networked Communication between Polymerase and Exonuclease Active Sites in Human Mitochondrial DNA Polymerase
High fidelity human mitochondrial DNA polymerase (Pol γ) contains two active sites, a DNA polymerization site (pol) and a 3′−5′ exonuclease site (exo) for proofreading. Although separated by 35 Å, coordination between the pol and exo sites is crucial to high fidelity replication. The biophysical mec...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7119269/ https://ncbi.nlm.nih.gov/pubmed/31251605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b04655 |
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