Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies

Replication errors are the main cause of mitochondrial DNA (mtDNA) mutations and a compelling approach to decrease mutation levels would therefore be to increase the fidelity of the catalytic subunit (POLγA) of the mtDNA polymerase. Here we genomically engineer the tamas locus, encoding fly POLγA, a...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Bratic, Ana, Kauppila, Timo E. S., Macao, Bertil, Grönke, Sebastian, Siibak, Triinu, Stewart, James B., Baggio, Francesca, Dols, Jacqueline, Partridge, Linda, Falkenberg, Maria, Wredenberg, Anna, Larsson, Nils-Göran
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773887/
https://ncbi.nlm.nih.gov/pubmed/26554610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9808
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