The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication

Mitochondrial DNA (mtDNA) polymerase γ (POLγ) harbours a 3′–5′ exonuclease proofreading activity. Here we demonstrate that this activity is required for the creation of ligatable ends during mtDNA replication. Exonuclease-deficient POLγ fails to pause on reaching a downstream 5′-end. Instead, the en...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Macao, Bertil, Uhler, Jay P., Siibak, Triinu, Zhu, Xuefeng, Shi, Yonghong, Sheng, Wenwen, Olsson, Monica, Stewart, James B., Gustafsson, Claes M., Falkenberg, Maria
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557304/
https://ncbi.nlm.nih.gov/pubmed/26095671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8303
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