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Calcitriol prevents RAD51 loss and cGAS-STING-IFN response triggered by progerin
Hutchinson Gilford Progeria Syndrome (HGPS) is a devastating accelerated aging disease caused by LMNA gene mutation. The truncated lamin A protein produced “progerin” has a dominant toxic effect in cells, causing disruption of nuclear architecture and chromatin structure, genomic instability, gene e...
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| Veröffentlicht in: | Proteomics |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7117971/ https://ncbi.nlm.nih.gov/pubmed/31834988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201800406 |
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