A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin

Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a truncated lamin A protein (progerin) that drives cellular and organismal decline. HGPS patient-derived fibroblasts accumulate genomic instability, but its underlying mechanisms and contribution to disease remain poo...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Kreienkamp, Ray, Graziano, Simona, Coll-Bonfill, Nuria, Bedia-Diaz, Gonzalo, Cybulla, Emily, Vindigni, Alessandro, Dorsett, Dale, Kubben, Nard, Batista, Luis Francisco Zirnberger, Gonzalo, Susana
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5848491/
https://ncbi.nlm.nih.gov/pubmed/29466729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.090
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