Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes

Hutchinson-Gilford Progeria Syndrome (HGPS) is a devastating incurable premature aging disease caused by accumulation of progerin, a toxic lamin A mutant protein. HGPS patient-derived cells exhibit nuclear morphological abnormalities, altered signaling pathways, genomic instability, and premature se...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kreienkamp, Ray, Croke, Monica, Neumann, Martin A., Bedia-Diaz, Gonzalo, Graziano, Simona, Dusso, Adriana, Dorsett, Dale, Carlberg, Carsten, Gonzalo, Susana
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper: Gerotarget (Focus on Aging)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058660/
https://ncbi.nlm.nih.gov/pubmed/27145372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9065
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