Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch

Upon DNA damage, the ALC1/CHD1L nucleosome remodeling enzyme (remodeler) is activated by binding to poly(ADP-ribose). How activated ALC1 recognizes the nucleosome, as well as how this recognition is coupled to remodeling, is unknown. Here, we show that remodeling by ALC1 requires a wild-type acidic...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Lehmann, Laura C., Bacic, Luka, Hewitt, Graeme, Brackmann, Klaus, Sabantsev, Anton, Gaullier, Guillaume, Pytharopoulou, Sofia, Degliesposti, Gianluca, Okkenhaug, Hanneke, Tan, Song, Costa, Alessandro, Skehel, J. Mark, Boulton, Simon J., Deindl, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116876/
https://ncbi.nlm.nih.gov/pubmed/33357431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108529
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