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Rapid discovery and evolution of orthogonal aminoacyl-tRNA synthetase–tRNA pairs
A central challenge in expanding the genetic code of cells to incorporate non-canonical amino acids into proteins is the scalable discovery of aminoacyl-tRNA synthetase (aaRS)–tRNA pairs that are orthogonal in their aminoacylation specificity. Here we computationally identify candidate orthogonal tR...
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| 出版年: | Nat Biotechnol |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7116527/ https://ncbi.nlm.nih.gov/pubmed/32284585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-0479-2 |
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