Molecular basis of β-arrestin coupling to formoterol-bound β(1)-adrenoceptor

The β(1)-adrenoceptor (β(1)AR) is a G-protein-coupled receptor (GPCR) that couples(1) to the heterotrimeric G protein G(s). G-protein-mediated signalling is terminated by phosphorylation of the C terminus of the receptor by GPCR kinases (GRKs) and by coupling of β-arrestin 1 (βarr1, also known as ar...

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Bibliographic Details
Published in:Nature
Main Authors: Lee, Yang, Warne, Tony, Nehmé, Rony, Pandey, Shubhi, Dwivedi-Agnihotri, Hemlata, Chaturvedi, Madhu, Edwards, Patricia C., Garcfa-Nafría, Javier, Leslie, Andrew G. W., Shukla, Arun K., Tate, Christopher G.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115876/
https://ncbi.nlm.nih.gov/pubmed/32555462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2419-1
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