Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis

Germinal center B cells (GCBCs) are critical for generating long-lived humoral immunity. How GCBCs meet the energetic challenge of rapid proliferation is poorly understood. Dividing lymphocytes typically rely on aerobic glycolysis over oxidative phosphorylation for energy. Here we report that GCBCs...

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Publicado no:Nat Immunol
Main Authors: Weisel, Florian J., Mullett, Steven J., Elsner, Rebecca A., Menk, Ashley V., Trivedi, Nikita, Luo, Wei, Wikenheiser, Daniel, Hawse, William F., Chikina, Maria, Smita, Shuchi, Conter, Laura J., Joachim, Stephen M., Wendell, Stacy G., Jurczak, Michael J., Winkler, Thomas H., Delgoffe, Greg M., Shlomchik, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112716/
https://ncbi.nlm.nih.gov/pubmed/32066950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-0598-4
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