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Of mice and men: murine bile acids explain species differences in the regulation of bile acid and cholesterol metabolism

Compared with humans, rodents have higher synthesis of cholesterol and bile acids (BAs) and faster clearance and lower levels of serum LDL-cholesterol. Paradoxically, they increase BA synthesis in response to bile duct ligation (BDL). Another difference is the production of hydrophilic 6-hydroxylate...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Lipid Res
Prif Awduron: Straniero, Sara, Laskar, Amit, Savva, Christina, Härdfeldt, Jennifer, Angelin, Bo, Rudling, Mats
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Biochemistry and Molecular Biology 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112145/
https://ncbi.nlm.nih.gov/pubmed/32086245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000307
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