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Of mice and men: murine bile acids explain species differences in the regulation of bile acid and cholesterol metabolism

Compared with humans, rodents have higher synthesis of cholesterol and bile acids (BAs) and faster clearance and lower levels of serum LDL-cholesterol. Paradoxically, they increase BA synthesis in response to bile duct ligation (BDL). Another difference is the production of hydrophilic 6-hydroxylate...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Straniero, Sara, Laskar, Amit, Savva, Christina, Härdfeldt, Jennifer, Angelin, Bo, Rudling, Mats
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112145/
https://ncbi.nlm.nih.gov/pubmed/32086245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000307
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