Of mice and men: murine bile acids explain species differences in the regulation of bile acid and cholesterol metabolism

Compared with humans, rodents have higher synthesis of cholesterol and bile acids (BAs) and faster clearance and lower levels of serum LDL-cholesterol. Paradoxically, they increase BA synthesis in response to bile duct ligation (BDL). Another difference is the production of hydrophilic 6-hydroxylate...

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Bibliographic Details
Published in:J Lipid Res
Main Authors: Straniero, Sara, Laskar, Amit, Savva, Christina, Härdfeldt, Jennifer, Angelin, Bo, Rudling, Mats
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2020
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112145/
https://ncbi.nlm.nih.gov/pubmed/32086245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000307
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