Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis

Idiopathic pulmonary fibrosis is a lung disease with limited therapeutic options that is characterized by pathological fibroblast activation and aberrant lung remodeling with scar formation. YAP (Yes-associated protein) is a transcriptional coactivator that mediates mechanical and biochemical signal...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Santos, Daniela M., Pantano, Lorena, Pronzati, Gina, Grasberger, Paula, Probst, Clemens K., Black, Katharine E., Spinney, Jillian J., Hariri, Lida P., Nichols, Royale, Lin, Yufei, Bieler, Michael, Seither, Peter, Nicklin, Paul, Wyatt, David, Tager, Andrew M., Medoff, Benjamin D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7110981/
https://ncbi.nlm.nih.gov/pubmed/31944822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2019-0296OC
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