Pretreatment of aged mice with retinoic acid supports alveolar regeneration via upregulation of reciprocal PDGFA signalling

OBJECTIVES: Idiopathic pulmonary fibrosis (IPF) primarily affects the aged population and is characterised by failure of alveolar regeneration, leading to loss of alveolar type 1 (AT1) cells. Aged mouse models of lung repair have demonstrated that regeneration fails with increased age. Mouse and rat...

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Detalhes bibliográficos
Publicado no:Thorax
Main Authors: Gokey, Jason J, Snowball, John, Green, Jenna, Waltamath, Marion, Spinney, Jillian J, Black, Katharine E, Hariri, Lida P, Xu, Yan, Perl, Anne Karina
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Interstitial Lung Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8070612/
https://ncbi.nlm.nih.gov/pubmed/33479039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2020-214986
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