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An Autotaxin-LPA-IL-6 Amplification Loop Drives Scleroderma Fibrosis
OBJECTIVE: We previously implicated the lipid mediator lysophosphatidic acid (LPA) in dermal fibrosis in systemic sclerosis (SSc). Here we identify the role of the LPA-producing enzyme autotaxin (ATX), and connect the ATX-LPA and IL-6 pathways in SSc. METHODS: We evaluated a novel ATX inhibitor, PAT...
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| Pubblicato in: | Arthritis Rheumatol |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5125861/ https://ncbi.nlm.nih.gov/pubmed/27390295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39797 |
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