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Genetic deletion or pharmacologic antagonism of LPA(1) ameliorates dermal fibrosis in a scleroderma mouse model
OBJECTIVE: Scleroderma, or systemic sclerosis (SSc), is characterized by progressive multi-organ fibrosis. We recently implicated lysophosphatidic acid (LPA) in the pathogenesis of pulmonary fibrosis. Here we investigated the roles of LPA and two of its receptors, LPA(1) and LPA(2), in dermal fibros...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3086986/ https://ncbi.nlm.nih.gov/pubmed/21305523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.30262 |
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