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LPA(1)-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation

There has been much recent interest in lysophosphatidic acid (LPA) signaling through one of its receptors, LPA(1), in fibrotic diseases, but the mechanisms by which LPA-LPA(1) signaling promotes pathological fibrosis remain to be fully elucidated. Using a mouse peritoneal fibrosis model, we demonstr...

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Detalhes bibliográficos
Main Authors: Sakai, Norihiko, Chun, Jerold, Duffield, Jeremy S., Wada, Takashi, Luster, Andrew D., Tager, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633809/
https://ncbi.nlm.nih.gov/pubmed/23322166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-219378
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